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当前位置: 首页 > 产品中心 > Primer_Probe > Empire Genomics/ALK Break Apart FISH Probe/ALKBA-20-ORGR/200 μL
商品详细Empire Genomics/ALK Break Apart FISH Probe/ALKBA-20-ORGR/200 μL
Empire Genomics/ALK Break Apart FISH Probe/ALKBA-20-ORGR/200 μL
Empire Genomics/ALK Break Apart FISH Probe/ALKBA-20-ORGR/200 μL
商品编号: ALKBA-20-ORGR
品牌: empiregenomics
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
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产品分类: 引物与探针
公司分类: Primer_Probe
联系Q Q: 3392242852
电话号码: 4000-520-616
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商品介绍

ALKBreakApartFISHProbe

AnaplasticlymphomakinasegenecodesfortheALKprotein,atyrosinekinasereceptor.Theseproteinsplayacrucialroleinintracellularsignaltransduction,allowingforcellgrowthanddifferentiation4.

AberrationsintheALKgene,includingoverexpression,deletionandmostcommonlytranslocation,havebeenfoundtoplayasignificantroleinthedevelopmentofover20differenttypesofcancers,especiallylungandlymph1.Astranslocationsmakeupalmost75%ofallgeneticabnormalitiesexhibitedincancercells,trackingALK’sintraandinterchromosomalmigrationcanbeusefulindiagnosisandtreatment3.

TheidentityofthegenethatALKfuseswithduringtranslocationisalsocriticalindeterminingtreatment,asdifferentfusionpartnershavebeenshowntoresponddifferentiallytochemodrugs2.AlthoughEML4remainsALK’smostprevalent,well-studiedfusionpartner,othergeneshavealsodemonstratedoncogeniceffectswhenconjoinedwithALK2,5.Infact,over30differentfusiongeneshavebeenidentified,albeitinlowerfrequenciesthanEML4,intumorsofALKassociatedcancers2.Thetypeandprevalenceofthesefusionproteinsarespecifictothetypeofcancerunderstudy,furtherproofofALK’sutilityindiagnosis1,2.

OurbreakapartprobescaneffectivelymapALKshuffling,whileourfusionprobescantestforthepresenceofspecificfusionproteinsifyoualreadyhaveatargetgeneinmind.

1.Shackelford,R.E.,Vora,M.,Mayhall,K.,&Cotelingam,J.(2014).ALK-rearrangementsandtestingmethodsinnon-smallcelllungcancer:areview.Genes&cancer,5(1-2),1-14.

2.Childress,M.A.,Himmelberg,S.M.,Chen,H.,Deng,W.,Davies,M.A.,&Lovly,C.M.(2018).ALKfusionpartnersimpactresponsetoALKinhibition:differentialeffectsonsensitivity,cellularphenotypes,andbiochemicalproperties.MolecularCancerResearch,16(11),1724-1736.

3.Futreal,P.A.,Coin,L.,Marshall,M.,Down,T.,Hubbard,T.,Wooster,R.,...&Stratton,M.R.(2004).Acensusofhumancancergenes.Naturereviewscancer,4(3),177.

4.https://ghr.nlm.nih.gov/gene/ALK

5.SABIr,S.,Yeoh,S.,Jackson,G.,&Bayliss,R.(2017).EML4-ALKvariants:BIOLOGicalandmolecularproperties,andtheimplicationsforpatients.Cancers,9(9),118.

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品牌介绍
Empire Genomics在各种血液和实体组织癌中已检测到不同类型的FGFR改变。在前列腺癌,乳腺癌,肺癌,脑癌,头颈癌和胃癌中已经注意到过表达/扩增。导致FGFR激酶结构域激活的融合蛋白在血液系统恶性肿瘤(包括多发性骨髓瘤和骨髓增生性疾病)中更为常见。我们的FGFR FISH面板包含用于检测与疾病相关的FGFR扩增,易位和融合的探针。